O56: Enhanced genomic and prognostic understanding of thoracic aortic aneurysms/dissections (TAAD): A study of 1,340 early-onset patients with extended follow-up
Abstract
Thoracic aortic aneurysms and dissections (TAAD) are life-threatening vascular disorders with substantial genetic contributions. Our prior single-center study of 1,095 TAAD patients identified a 34.2% genetic diagnostic yield, established FBN1 as the dominant pathogenic driver, and linked positive results to higher reintervention risk. However, that study was limited by a mixed-age cohort and short follow-up (median 3.86 years). To refine genotype–phenotype and prognostic correlations, we conducted an expanded analysis focusing on early-onset cases (≤40 years) with extended follow-up.
Fields of Study & Subjects
Connective tissue disorders research
Aortic Disease and Treatment Approaches
Aortic aneurysm repair treatments
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 104347–104347
- Publication date
- 1 January 2026
- Language
- EN