O59: Combined donor and immune cell-free DNA signatures to enhance accurate detection of cardiac allograft rejection

Genetics in Medicine Open 2026 Open access

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Authors: Temesgen Ewunetu Andargie, Tom Hill, Sheng Fu, Hyesik Kong, Kai Yu, Moon Kyoo Jang, Sean T. Agbor-Enoh
DOI: 10.1016/j.gimo.2026.104350
Cited by: 0

Abstract

Diagnostic approaches for cardiac acute rejection predominantly focus on assessing the allograft, often neglecting the concurrent immune responses activated during transplant rejection that may lead to the release of immune cell-derived cell-free DNA (cfDNA). This proof-of-concept study evaluates the diagnostic performance of a cfDNA approach that measures both donor and recipient immune cell compartments in relation to cardiac allograft rejection.

Fields of Study & Subjects

Transplantation: Methods and Outcomes Organ and Tissue Transplantation Research Renal Transplantation Outcomes and Treatments

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
104350–104350
Publication date
1 January 2026
Language
EN