Health actions after direct-to-consumer genetic testing for medically actionable conditions

Purpose: Millions of individuals have undergone direct-to-consumer genetic testing (DTC-GT), which can include results for medically actionable conditions. We sought to determine whether individuals with DTC-GT results for medically actionable cancer and cardiovascular conditions take health actions, such as sharing results with health care professionals (HCPs) and following subsequent recommendations to reduce health risks. Methods: and had opened their report. Main outcomes included personal and family history of relevant health conditions, prior genetic testing, result sharing with biological relatives and HCPs, HCP recommendations, and adherence to recommendations. Results: (24.0%). Among individuals who shared results with HCPs, 86.0% received at least 1 medical recommendation, and 87.5% of recommendations were followed. Conclusion: Most individuals receiving medically actionable results through DTC-GT had no prior knowledge of their genetic health risks, despite many reporting a relevant personal and/or family history. When individuals shared results with HCPs and received medical recommendations, adherence was high.