Carbohydrate-based vaccine engineering (CVE): An integrated strategy against bacterial infections
Abstract
Carbohydrate-based vaccines are an effective means for combating bacterial infections, particularly in the face of rising antibiotic resistance. This perspective provides an overview of carbohydrate vaccine against bacterial infections, from the earliest polysaccharide formulations to the latest synthetic constructs, and highlights the full engineering continuum encompassing carbohydrate antigen production, epitope mapping, conjugation chemistry, formulation, preclinical and clinical evaluation, and regulatory approval. By introducing the integrative framework of carbohydrate-based vaccine engineering (CVE), a unified perspective is provided to support both the optimization of current vaccine platforms and the rational design of next-generation glycoconjugate vaccines.
Fields of Study & Subjects
Carbohydrate Chemistry and Synthesis
Escherichia coli research studies
Glycosylation and Glycoproteins Research
Publication details
- Journal / source
- Glycoscience & Therapy
- Publisher
- Elsevier BV
- Volume
- 2
- Issue
- 2
- Pages
- 100039–100039
- Publication date
- 7 March 2026
- Language
- EN