Cobalt-catalyzed enantioselective hydroalkylation of oxanorbornene for the construction of chiral bridged oxabicyclic structures

Green Synthesis and Catalysis 2026 Open access

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Authors: Zheng Sun, Ronghao Zhao, Jie Chen, LongPing LI, Fangzhi Peng, Run Tian, Long Li, Zhihui Shao
DOI: 10.1016/j.gresc.2026.01.003
Cited by: 2
References: 66

Abstract

ABSTRACT Available online Oxanorbornene is a versatile building block in natural product and pharmaceutical synthesis, yet its enantioselective hydroalkylation with bridged ring retention remains underdeveloped. Herein, we report a cobalt-catalyzed enantioselective hydroalkylation of oxanorbornene. Using low-cost cobalt, no directing groups, and under mild conditions, it constructs oxabicyclic products with intact bridged rings, featuring broad substrate scope and good enantioselectivity (up to 78% yield, up to 95:5 er ).

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Asymmetric Hydrogenation and Catalysis Organometallic Complex Synthesis and Catalysis

Publication details

Journal / source
Green Synthesis and Catalysis
Publisher
Elsevier BV
Publication date
1 January 2026
Language
EN