“Real-world prognostic performance of different severe and advanced heart failure definitions: Data from the Swedish Heart Failure Registry”

The Journal of Heart and Lung Transplantation 2026 Open access

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Authors: Federica Guidetti, Lars Christian; id_orcid 0000-0001-8651-6072 Lund, Lina Benson, Camilla Hage, Felix Lindberg, Christian Basile, Alessandro Villaschi, Francesca Musella, Davide Stolfo, R Scorza, Guillame Baudry, Charlotta Ljungman
+5 more Oscar Braun, Valeria Valente, Biykem Bozkurt, Marco Metra, Gianluigi Savarese
DOI: 10.1016/j.healun.2026.03.008
Cited by: 3
References: 29

Abstract

BACKGROUND: A valid definition of severe heart failure (HF) is essential for earlier identification, timely referral for advanced therapies, and to optimize clinical trial design. OBJECTIVES: To assess the prevalence, prognostic performance, and 1-year outcomes associated with different definitions of severe and advanced HF (AdvHF) in patients with heart failure with reduced ejection fraction (HFrEF). METHODS: We included 15,153 patients with EF 6 months, and no prior left ventricular assist device or heart transplant, from the Swedish Heart Failure Registry. Several definitions of severe/AdvHF were evaluated: a simplified Heart Failure Association (HFA) definition (NYHA III-IV, EF

Fields of Study & Subjects

Heart Failure Treatment and Management Cardiovascular Function and Risk Factors Acute Myocardial Infarction Research

Publication details

Journal / source
The Journal of Heart and Lung Transplantation
Publisher
Elsevier BV
Volume
45
Issue
9
Pages
1380–1393
Publication date
18 March 2026
Language
EN