Gold nanoparticle-based lateral flow immunoassay for detection of urinary 8-hydroxy-2ʹ-deoxyguanosine in preterm infants: A promising tool for pain-free, low-cost, and bedside screening of retinopathy of prematurity

Heliyon 2026 Open access

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Authors: Abilash Gangula, Varsha Srinivasan, Shreya Ghoshdastidar, Jagjot Kainth, Keerthivaas Premkumar, Lila S. Nolan, Raghuraman Kannan, John Pardalos, Dean P. Hainsworth, Anandhi Upendran
DOI: 10.1016/j.heliyon.2026.e44515
Cited by: 1
References: 43

Abstract

Purpose The clinical gold standard for screening of retinopathy of prematurity (ROP) in preterm infants involves binocular indirect ophthalmoscopy (BIO), an expensive, stressful, and not easily accessible procedure. In this study, we present the development of gold nanoparticle-based lateral flow immunoassay (LFIA) as an alternative screening procedure for ROP to reduce the burden of BIO. Design Prospective clinical study. Methods 23 pre-terms were enrolled for the study. Infants with the expected length of stay of

Fields of Study & Subjects

Retinopathy of Prematurity Studies Neonatal and Maternal Infections Neonatal Health and Biochemistry

Publication details

Journal / source
Heliyon
Publisher
Elsevier BV
Volume
12
Issue
2
Pages
e44515–e44515
Publication date
10 January 2026
Language
EN