Endothelial disruption: A new complication during pulsed field ablation using a pentaspline catheter
Abstract
Pulsed field ablation (PFA) is an emerging nonthermal ablation technique that is increasingly being used for the treatment of atrial fibrillation (AF). It works by delivering rapid intermittent high-voltage pulses to myocardial tissue, inducing irreversible electroporation—a process that increases membrane permeability, disrupts cellular homeostasis, and promotes death of affected cells via apoptosis, necrosis, necroptosis, and pyroptosis.1,2 PFA has been shown to be safe and effective in achieving pulmonary vein isolation (PVI), while sparing damage to collateral structures such as the esophagus, phrenic nerve, and distal pulmonary veins—injuries more classically associated with traditional thermal ablation techniques.
Fields of Study & Subjects
Cardiac Arrhythmias and Treatments
Microbial Inactivation Methods
Ultrasound and Hyperthermia Applications
Publication details
- Journal / source
- HeartRhythm Case Reports
- Publisher
- Elsevier BV
- Volume
- 12
- Issue
- 7
- Pages
- 689–692
- Publication date
- 30 January 2026
- Language
- EN