Perinatal management of congenital long QT syndrome: A case of maternal and fetal manifestations

HeartRhythm Case Reports 2026 Open access

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Authors: Manuela Silva Lopes, João Dias, Iolanda Ferreira, Catarina Miranda Silva, Ana Rita Ramalho, Joana Rosmaninho‐Salgado, Maria Emanuel Amaral, Helena Andrade, Paula Martins, António Pires
DOI: 10.1016/j.hrcr.2026.02.020
Cited by: 0
References: 14

Abstract

Congenital long QT syndrome (LQTS) encompasses a group of heritable channelopathies characterized by cardiac repolarization dysfunction and an increased risk of ventricular arrhythmias. The three major autosomal dominant subtypes (types I, II, and III) are linked to mutations in cardiac potassium and sodium ion channels, leading to prolonged QTc intervals. Over 75% of cases are attributed to mutations in three primary genes: KCNQ1, KCNH2 (potassium channels) and SCN5A (sodium channels) (1).

Fields of Study & Subjects

Cardiac electrophysiology and arrhythmias Cardiovascular Issues in Pregnancy Ion channel regulation and function

Publication details

Journal / source
HeartRhythm Case Reports
Volume
12
Issue
6
Pages
649–654
Publication date
5 March 2026
Language
EN