Proposed workflow for the prevention of lead-related superior vena cava syndrome

Heart Rhythm O2 2026 Open access

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Authors: Fenna Daniëls, Erik Lipšic, Hessel F. Groenveld, Michiel Rienstra, Alexander H. Maass
DOI: 10.1016/j.hroo.2026.01.025
Cited by: 0
References: 11

Abstract

In this viewpoint, after an overview of the background of lead-related superior vena cava (SVC) syndrome, we propose a structured clinical workflow intended to reduce the risk of lead-related SVC syndrome. Superior vena cava (SVC) syndrome is a rare condition of stenosis of the SVC resulting in symptoms. In the majority of 60% of the patients, SVC syndrome is caused by a malignancy. However, in approximately 30% of all the patients with SVC syndrome, it is related to cardiac implantable electronic device (CIED) leads and central venous catheters (CVC).

Fields of Study & Subjects

Central Venous Catheters and Hemodialysis Vascular anomalies and interventions Cardiac pacing and defibrillation studies

Publication details

Journal / source
Heart Rhythm O2
Volume
7
Issue
4
Pages
810–812
Publication date
31 January 2026
Language
EN