Acute hemodynamic effects of a novel algorithm for cardiac resynchronization therapy optimization: Results from the BIO|Adapt study

Heart Rhythm O2 2026 Open access

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Authors: F. Fernandez, Kenji Andò, Ritsushi Kato, Juan Gabriel Martínez, Antonio Berruezo, Javier Jimenez, Lars Anneken, Naoya Hironobe, Masahide Harada, Atsuhiko Yagishita, Joaquín Osca-Asensi, Przemyslaw P. Mitkowski
+10 more Hidemori Hayashi, Jun Kishihara, Mónica Pardo-Fresno, Iftikhar O Ebrahim, Jürgen Meyhöfer, Rafael Salguero Bodes, P M Pedro Marques, Alicia Moreno, Mariona Pinart, Alan Bulava
DOI: 10.1016/j.hroo.2026.01.030
Cited by: 0
References: 24

Abstract

Background A considerable proportion of heart failure patients with reduced left ventricular ejection fraction (LVEF) and prolonged QRS duration fail to respond adequately to Cardiac resynchronization therapy (CRT). Suboptimal atrioventricular (AV) delay programming is a key factor leading to diminished response. Objective To acutely correlate aortic velocity time integral (AoVTI), LVEF, and QRS duration with three programming strategies in the post-implantation setting: AV delay automatically set by a novel CRT AutoAdapt algorithm, AV delay optimized by echocardiography, and standard (‘in-box') programming. Methods Under normal intrinsic AV conduction (

Fields of Study & Subjects

Cardiac pacing and defibrillation studies Cardiac Arrest and Resuscitation Cardiac electrophysiology and arrhythmias

Publication details

Journal / source
Heart Rhythm O2
Volume
7
Issue
4
Pages
686–694
Publication date
4 February 2026
Language
EN