Urine NGAL adds to serum creatinine in predicting cefepime clearance in critically ill children at high risk of acute kidney injury

Horace Rhodes Hambrick; Ronaldo Morales; Calise Curry; Michaela Collins; Luana Johnson; Tomoyuki Mizuno; Kelli A. Krallman; Stuart L. Goldstein; Sonya Tang Girdwood

doi:10.1016/j.ijantimicag.2026.107741

Urine NGAL adds to serum creatinine in predicting cefepime clearance in critically ill children at high risk of acute kidney injury

International Journal of Antimicrobial Agents 2026 Open access

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Authors: Horace Rhodes Hambrick, Ronaldo Morales, Calise Curry, Michaela Collins, Luana Johnson, Tomoyuki Mizuno, Kelli A. Krallman, Stuart L. Goldstein, Sonya Tang Girdwood

DOI: 10.1016/j.ijantimicag.2026.107741

Cited by: 0

References: 36

Abstract

• Adding urine neutrophil gelatinase-associated lipocalin, or uNGAL, to a serum creatinine-based cefepime population pharmacokinetic model improves prediction of cefepime clearance , identifying children at risk for altered drug exposure early in critical illness. • Elevated uNGAL (≥500 ng/mL) was associated with ∼35% lower cefepime clearance after accounting for creatinine-based estimated glomerular filtration rate. • Patients with a low (

Fields of Study & Subjects

Antibiotics Pharmacokinetics and Efficacy Acute Kidney Injury Research Pharmaceutical studies and practices

Publication details

Journal / source: International Journal of Antimicrobial Agents
Volume: 67
Issue: 5
Pages: 107741–107741
Publication date: 12 February 2026
Language: EN

References 36