Validation of NT-proBNP cutoff points for heart failure diagnosis in adults with CHD in the outpatient clinic and emergency department
Abstract
Background: Empirical data support the use of N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) for heart failure (HF) rule-in and rule-out in patients with acquired heart disease, but similar data are lacking in adults with congenital heart disease (CHD). The purpose of this study was to assess diagnostic performance of conventional NT-proBNP cutoff points for HF diagnosis (rule-in and rule-out) in adults with CHD. Method: Retrospective study of adults with CHD and NT-proBNP measurement in the outpatient clinic (outpatient cohort) or in the emergency department (ED) (2003-2023). HF diagnosis was based on clinical assessment at the time of NT-proBNP measurement. Logistic regression was used to assess the diagnostic performance of conventional NT-proBNP cutoff points (
Fields of Study & Subjects
Heart Failure Treatment and Management
Cardiac pacing and defibrillation studies
Cardiac Structural Anomalies and Repair
Publication details
- Journal / source
- International Journal of Cardiology Congenital Heart Disease
- Publisher
- Elsevier BV
- Volume
- 24
- Pages
- 100675–100675
- Publication date
- 8 April 2026
- Language
- EN