Elevated lipoprotein(a) and adverse outcomes in advanced coronary artery calcification: An intravascular ultrasound study

International Journal of Cardiology Cardiovascular Risk and Prevention 2026 Open access

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Authors: Shaowu Xiao, Mengya Zeng, Junru He, Dabao Xiao, Yuewu Chen
DOI: 10.1016/j.ijcrp.2026.200606
Cited by: 2
References: 26

Abstract

Background: Coronary artery calcification (CAC) signifies advanced atherosclerosis and portends increased cardiovascular risk. Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerosis; however, its association with in vivo lesion morphology and clinical outcomes in patients with symptomatic, advanced CAC remains incompletely characterized. Objective: This study aimed to investigate the association between elevated Lp(a) levels and both in vivo lesion morphology and clinical outcomes in this high-risk population. Methods: In this retrospective cohort, 292 patients with intravascular ultrasound(IVUS)-confirmed CAC were stratified into elevated (≥50 mg/dL,n = 77) or low (

Fields of Study & Subjects

Lipoproteins and Cardiovascular Health Coronary Interventions and Diagnostics Peripheral Artery Disease Management

Publication details

Journal / source
International Journal of Cardiology Cardiovascular Risk and Prevention
Publisher
Elsevier BV
Volume
29
Pages
200606–200606
Publication date
21 February 2026
Language
EN