Genomic epidemiology and evolutionary dynamics of Bordetella pertussis: A comparative study between China and Global Strains (2018–2024)

International Journal of Infectious Diseases 2026 Open access

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Authors: Jianguang Cai, Y W Zhang, Shuang Wu, Peihui Liu, Shuxiang Qiu, Qiongcheng Chen, Wenkai Cui, Shiting Chen, Wen Li, Xuan Zou, Qinghua Hu, Bo Peng
+4 more Yixiang Jiang, Min Jiang, Pan Zhang, Xiaolu Shi
DOI: 10.1016/j.ijid.2026.108397
Cited by: 1
References: 46

Abstract

OBJECTIVES: This study aimed to elucidate the global origins, evolutionary trajectory, and adaptive strategies of the MT28-ptxP3 macrolide-resistant Bordetella pertussis lineage driving the recent resurgence. METHODS: We integrated long-term epidemiologic surveillance data from Shenzhen (2013-2024) with comparative genomic analysis of 632 isolates (2018-2024), including early international MT28 strains from the United States, Japan, Austria, and Vietnam. Multilocus variable-number tandem-repeat analysis and single-nucleotide polymorphism-based phylogenetics were used to define population structure and evolutionary dynamics. RESULTS: The study revealed a dramatic clonal replacement: the MT28 lineage surged from 6.5% in 2018 to 89.4% in 2024 (P

Fields of Study & Subjects

Bacterial Infections and Vaccines Pneumonia and Respiratory Infections Virology and Viral Diseases

Publication details

Journal / source
International Journal of Infectious Diseases
Publisher
Elsevier BV
Volume
165
Pages
108397–108397
Publication date
23 January 2026
Language
EN