TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

International Journal for Parasitology Drugs and Drug Resistance 2026 Open access

Read full text
Authors: Claudia M. Rohr, Sang-Kyu Park, Kelsilandia Aguiar-Martins, Timothy J.C. Anderson, Duncan Berger, Matthew Berriman, Sarah K. Buddenborg, Amaya L. Bustinduy, Frédéric D. Chevalier, James A. Cotton, Thomas Crellen, Stephen R. Doyle
+15 more Aidan M. Emery, Julien Kincaid Smith, Safari Kinung'hi, Poppy H.L. Lamberton, Winka Le Clec’h, Eric M. Ndombi, Tom Pennance, Candia Rowel, Shannan Summers, John Vianney Tushabe, Martin Walker, Bonnie L. Webster, Joanne P. Webster, Shona Wilson, Jonathan S. Marchant
DOI: 10.1016/j.ijpddr.2026.100639
Cited by: 2
References: 51

Abstract

variants have been functionally profiled, where geographically these variants have been found, their frequency within populations, and their potential impact on PZQ sensitivity. The overall goal is to facilitate rapid community-wide exchange of data to monitor predicted variants of concern that are likely to be associated with decreased PZQ efficacy.

Fields of Study & Subjects

Genomics and Rare Diseases Genetics and Neurodevelopmental Disorders Ion channel regulation and function

Publication details

Journal / source
International Journal for Parasitology Drugs and Drug Resistance
Publisher
Elsevier BV
Volume
30
Pages
100639–100639
Publication date
18 March 2026
Language
EN