Epidemiology, clinical features, and outcomes of Mpox in children and adolescents in Uganda, August 2024–January 2025

IJID Regions 2026 Open access

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Authors: Charity Mutesi, Richard Migisha, Emmanuel Okiror Okello, Emmanuel Mfitundinda, Janet Kobusinge Lubega, Patrick Kwizera, Joanita Nalwanga, Hannington Katumba, Joyce Owens Kobusingye, Gertrude Abbo, Daniel Wenani, Bridget Ainembabazi
+6 more Olive Namakula Loryndah, Annet Mary Namusisi, Lilian Bulage, Ivan Lukabwe, Dansan Atim, Alex Riolexus Ario
DOI: 10.1016/j.ijregi.2026.100838
Cited by: 3
References: 18

Abstract

Objectives: Recent Mpox outbreaks in Uganda have primarily affected adults, but children and adolescents are at a higher risk of severe disease. We described the epidemiology, severity, and factors associated with severe Mpox among children and adolescents in Uganda during August 2024-January 2025. Methods: We conducted a cross-sectional study among polymerase chain reaction-confirmed Mpox cases in patients aged 0-17 years in eight high-burden districts. Medical records were reviewed, and Mpox severity was measured using the severity scoring system. Participants' variables were summarized using descriptive statistics and attack rates. Modified Poisson regression identified factors associated with severe disease. Results: Among 160 case-patients, males (attack rate [AR] = 2.2/100,000) and females (AR = 2.1/100,000) were equally affected. Children

Fields of Study & Subjects

Poxvirus research and outbreaks Virology and Viral Diseases Vaccine Coverage and Hesitancy

Publication details

Journal / source
IJID Regions
Publisher
Elsevier BV
Volume
18
Pages
100838–100838
Publication date
8 January 2026
Language
EN