18F-Fluciclovine for Detection of Recurrent Brain Metastases After Radiation Therapy: Image Interpretation Criteria and Diagnostic Performance From the PURSUE Study

International Journal of Radiation Oncology*Biology*Physics 2026 Open access

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Authors: Rupesh Kotecha, Veronica Chiang, Martin C. Tom, Ephraim E. Parent, Ali Nabavizadeh, B.V. Siegel, Jiayi Huang, Elçin Zan, Srinivas Peddi, Steven Brem, M. Ware, Erik P. Sulman
+20 more Santosh Kesari, Whitney Pope, Robin Holmes, Albert Chau, Eugene Teoh, Samuel T Chao, Mariam Aboian, Marissa Barbaro, Surya Chundru, Stephen Fogelson, Manu S. Goyal, Albert H. Kim, Douglas Kondziolka, Goldie Kurtz, Mary Lokuta, Minesh P. Mehta, Matthew P. Miller, Yazmin Odia, Maria Rosana Ponisio, Sharon Weick
DOI: 10.1016/j.ijrobp.2026.02.239
Cited by: 2
References: 30

Abstract

BACKGROUND : Differentiating recurrent brain metastases (BM) from treatment-related changes post-radiotherapy remains challenging. PURSUE (NCT04410367) evaluated various lesion uptake metrics to establish image interpretation criteria to detect recurrent BM with 18 F-fluciclovine PET. METHODS : Patients with BM were enrolled if they had a previously irradiated MRI-equivocal ‘reference' lesion and were planned for craniotomy. PET with 18 F-fluciclovine (185 MBq) was performed

Fields of Study & Subjects

Brain Metastases and Treatment Glioma Diagnosis and Treatment Medical Imaging Techniques and Applications

Publication details

Journal / source
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Volume
125
Issue
5
Pages
1410–1420
Publication date
26 February 2026
Language
EN