Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection

Immunity 2026 Open access

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Authors: Anaïs. Compositeur présumé Roger, Tiphaine Fohrer, Ugo Mardelle, Isaac Thomas, Sara Teimouri Nezhad, Surbhi Gupta, Alissa Dory, Vidthiya Jeyanathan, Andisheh Liaghat, Julie Mielle, Hakim Medjouel Khlifi, Jérémy C. Santamaria
+20 more Elena Brunet, Jordi Gouilly, Bertrand Escalière, Ninon Bretaud, Théo Crosson, Pierre-Vincent Barbon, Noushin Mossadegh-Keller, Magali Irla, Sam Basta, Achille Broggi, Pierre Milpied, Naina Gour, Vincent Feuillet, Guillaume Hoeffel, Xinzhong Dong, Eva Kaufmann, Ana Reynders, Sébastien Talbot, Aziz Moqrich, Sophie Ugolini
DOI: 10.1016/j.immuni.2026.01.022
Cited by: 5
References: 79

Abstract

sensory neurons limited neutrophil infiltration through the Mas-related G protein-coupled receptor member A1 (MRGPRA1) receptor and promoted skin healing, revealing an unexpected anti-inflammatory role for this neuropeptide. In infected DRGs, a TAFA4-interleukin (IL)-10 pathway promoted the resolution of inflammation after viral clearance. Together, these neuroimmune regulatory pathways reduced the detrimental impact of the infection on host fitness without directly altering pathogen elimination, revealing how the sensory nervous system has developed several mechanisms to promote disease tolerance.

Fields of Study & Subjects

Neuropeptides and Animal Physiology Pharmacological Receptor Mechanisms and Effects Nicotinic Acetylcholine Receptors Study

Publication details

Journal / source
Immunity
Publisher
Elsevier BV
Volume
59
Issue
3
Pages
682–699.e8
Publication date
25 February 2026
Language
EN