UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes

Immunity 2026 Open access

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Authors: Jennifer A. Lo, Inbal Rachmin, Jessica L. Flesher, Xunwei Wu, Akinori Kawakami, Miroslav Hejna, Judth R. Boozer, Nhu Nguyen, Andrew King, Yawen Ji, Sharon Germana, Lajos V. Kemeny
+24 more Anita A. J. van der Sande, Jeffrey B. Cheng, Michal Lotem, Torrey R. Utne, Yao Zhan, Elisabeth M. Roider, Nisma Mujahid, Elizabeth H. Byrne, Shailbala Singh, Manoubia Saidani, Sabrina Martineau, Nathalie Holic, Christine Baldeschi, Cécile Martinat, Gordon J. Freeman, Nir Hacohen, Keith T. Flaherty, Genevieve M. Boland, Jun S. Song, Arlene H. Sharpe, Shadmehr Demehri, Cassian Yee, Jennifer Allouche, David E. Fisher
DOI: 10.1016/j.immuni.2026.07.018
Cited by: 1
References: 78

Fields of Study & Subjects

melanin and skin pigmentation Skin Protection and Aging Melanoma and MAPK Pathways

Publication details

Journal / source
Immunity
Publisher
Elsevier BV
Volume
59
Issue
9
Pages
2500–2514.e8
Publication date
13 August 2026
Language
EN