Primary mixed yolk sac tumor and germinoma arising from conus medullaris and filum terminale: A case report and literature review

Background Primary spinal germ cell tumors are exceedingly rare, and standardized treatment strategies remain undefined. Case report We report a rare case of a mixed germ cell tumor composed of germinoma and yolk sac tumor located in the conus medullaris and filum terminale. The patient underwent partial resection followed by chemotherapy with cisplatin, etoposide, and cyclophosphamide, and craniospinal (23.4 Gy) plus local (50.6 Gy) irradiation. Post-treatment MR imaging showed marked regression of the residual tumor. Conclusion This case highlights the diagnostic importance of histopathology and suggests that combined chemotherapy and craniospinal plus local irradiation may be effective for tumor control in spinal germ cell tumors.