BCL-11 enables adaptive stress responses to environmental challenges

iScience 2026 Open access

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Authors: Patrizia Niedworok, Rossella Erminia Ciliberti, Beijia Xie, Amal John Mathew, Benjamin Jussila, Jennifer A. Lawson, Elena De Domenico, Stefan Paulusch, Marc Beyer, Pierluigi Nicotera, N. Ahmad Aziz, Dan Ehninger
+2 more Sandra Blaess, Daniele Bano
DOI: 10.1016/j.isci.2025.114422
Cited by: 0
References: 58

Abstract

mutants, suggesting a transcriptional interplay between BCL-11 and DAF-16 in IIS-deficient animals. Together, our data suggest that BCL-11 actively regulates transcription during development, while in adult animals it is recruited in response to environmental insults to enhance stress resilience.

Fields of Study & Subjects

Genetics Aging and Longevity in Model Organisms FOXO transcription factor regulation Endoplasmic Reticulum Stress and Disease

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114422–114422
Publication date
7 January 2026
Language
EN