A nuclear isoform of hydroxyacyl-COA dehydrogenase inhibits tumor progression in colorectal cancer

iScience 2026 Open access

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Authors: Yunyi Gao, Lei Yu, Jingyu Hou, Yuchun Hong, Xiangwei Gao, Zhanghui Chen
DOI: 10.1016/j.isci.2025.114470
Cited by: 0
References: 36

Abstract

. Mechanistically, HADH-S antagonizes protein arginine methyltransferase 5 (PRMT5)-mediated histone arginine methylation, thereby facilitating gene transcription. Notably, HADH promotes the transcription of the Wnt suppressor AXIN2. These findings collectively identify a novel nuclear isoform of HADH that exerts inhibitory effects on colorectal tumorigenesis.

Fields of Study & Subjects

Cancer-related gene regulation Folate and B Vitamins Research Microbial metabolism and enzyme function

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114470–114470
Publication date
10 January 2026
Language
EN