Thrombospondin 1 aggravates cardiac remodeling in heart failure with preserved ejection fraction by inhibiting mitophagy

iScience 2026 Open access

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Authors: Xingpeng Bu, Shuo Sha, Zhenzhen Zhang, Sicheng Bian, Shuhui Feng, Chunxia Li, Lei Wang, Huanzhen Chen

DOI: 10.1016/j.isci.2026.114639

Cited by: 1

References: 48

Abstract

as a key suppressor of mitophagy in HFpEF and a potential therapeutic target for this prevalent condition.

Cardiac Fibrosis and Remodeling Cardiovascular Function and Risk Factors Autophagy in Disease and Therapy

References 48