Hyperlipidemia exacerbates frozen shoulder fibrosis by activating the TGF-β/Smad2/3 signaling pathway via the TBX5-TNC-Itgα2 axis

iScience 2026 Open access

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Authors: Fan Jiang, Yi Zhang, Jinlong Ma, Tengbo Yu, Youliang Shen
DOI: 10.1016/j.isci.2026.114660
Cited by: 0
References: 52

Abstract

targeting of TBX5 significantly mitigated both mobility loss and joint capsule fibrosis in the hyperlipidemic rat model. This work defines the TBX5-TNC-Itgα2 axis as a novel molecular bridge connecting systemic HL to localized pathology, identifying critical targets for developing precision anti-fibrotic therapies.

Fields of Study & Subjects

Shoulder Injury and Treatment Tendon Structure and Treatment Musculoskeletal synovial abnormalities and treatments

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114660–114660
Publication date
9 January 2026
Language
EN