FAM65A, as a potential predictor of prognosis, promotes colorectal cancer progression via activating Ras/ERK/RSK signaling

iScience 2026 Open access

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Authors: Yuqiu Ma, Jie Yao, Xinzhuang Shen, Shuying Wang, Gongli Tang, Xiaowen Yang, Yifei Li, Yifang Sun, Wenzhi Shen, Xiaoyuan Zhang, Yongming Huang
DOI: 10.1016/j.isci.2026.114662
Cited by: 1
References: 27

Abstract

experiments indicated that FAM65A knockdown led to the inhibition of Ras/ERK/RSK activation and subsequently impeded CRC progression. Our study provides targets and strategies for the treatment of CRC.

Fields of Study & Subjects

Cancer Mechanisms and Therapy Wnt/β-catenin signaling in development and cancer Aldose Reductase and Taurine

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114662–114662
Publication date
10 January 2026
Language
EN