ACTG1 facilitates proliferation and epithelial-mesenchymal transition-mediated metastasis via COL21A1 in gastric cancer

iScience 2026 Open access

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Authors: Shoumin Li, Bingxue Lan, Li Pan, Ming Sun, Miaomiao Cui, Yun Huang, Sixi Wei, Hai Huang
DOI: 10.1016/j.isci.2026.114666
Cited by: 1
References: 38

Abstract

models. Transcriptomic sequencing identified COL21A1 as a key downstream effector, and KEGG analysis indicated involvement in epithelial-mesenchymal transition (EMT). Critically, overexpression of COL21A1 rescued the inhibitory effects of ACTG1 knockdown on proliferation, migration, and EMT. These findings demonstrate that the ACTG1/COL21A1 axis promotes GC progression by regulating EMT, highlighting its potential as a therapeutic target for patients with GC.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Chromatin Remodeling and Cancer Genetic factors in colorectal cancer

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114666–114666
Publication date
23 January 2026
Language
EN