Biosynthesis of polyamine-polyphosphate granules for colitis alleviation

iScience 2026 Open access

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Authors: Zihao Fan, Xuena Zhang, Xiaotong Ge, Lei Zhu, Minsheng Zhu, Liuyan Yang
DOI: 10.1016/j.isci.2026.114679
Cited by: 1
References: 51

Abstract

. Notably, the oral administration of PPGs increased colonic polyamine levels, alleviated DSS-induced colitis, reduced inflammatory cytokines, and restored gut microbiota balance. Overall, biosynthesized PPGs represent a highly promising material for mitigating colitis.

Fields of Study & Subjects

Polyamine Metabolism and Applications Coagulation Bradykinin Polyphosphates and Angioedema Biopolymer Synthesis and Applications

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114679–114679
Publication date
13 January 2026
Language
EN