Platelet membrane-camouflaged matrine biomimetic nanoparticles for efficient acute lung injury therapy

iScience 2026 Open access

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Authors: Yinqiang Fan, Haiyuan Zhang, Xingxing Chai, Jiahao Liu, Yinlian Yao, Xin Shen, Ru Li, Ning Wei, Meiting Yang, Lixia Li, Xiaolei Zhao, Yue Zhao
+1 more Hua Jin
DOI: 10.1016/j.isci.2026.114683
Cited by: 0
References: 20

Abstract

. In an ALI mouse model, PM@Mat-NPs selectively accumulated in inflamed lung tissue, significantly reduced pro-inflammatory cytokines (TNF-α, IL-6), and alleviated histological damage. They also suppressed NLRP3 inflammasome activation and apoptosis, outperforming free matrine. Biosafety evaluations confirmed no significant adverse effects. This study introduces a biomimetic nano-platform for the targeted delivery of Chinese herbal components, offering a promising strategy for treating acute lung injury.

Fields of Study & Subjects

Nanoparticle-Based Drug Delivery Inhalation and Respiratory Drug Delivery Pharmacology and Nanomedicine Research

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114683–114683
Publication date
13 January 2026
Language
EN