HHEX-PRKAR2B axis-mediated PKA activation drives glucose metabolism-dependent progression of pancreatic ductal adenocarcinoma

iScience 2026 Open access

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Authors: Junxiang Wen, Qiuchen Li, Shuxiang Xu, Wenjun Lu, Fei Wu, Jiatao Lou, Lin Wang
DOI: 10.1016/j.isci.2026.114691
Cited by: 1
References: 62

Abstract

, high glucose synergized with PKA activation to promote metastasis, whereas glycolysis inhibition blocked new metastases. Thus, HHEX-PRKAR2B-mediated PKA activation is a critical hub for PDAC progression, modulated by glucose and reinforcing glycolysis via HK2, revealing novel therapeutic targets for metabolic intervention.

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Pancreatic function and diabetes Metabolism Diabetes and Cancer

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114691–114691
Publication date
14 January 2026
Language
EN