Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production

iScience 2026 Open access

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Authors: Zixian Wang, Yanxi Chen, Yongqi Feng, Gaoyu Zu, Wenxu Wang, Limiao Liang, Xinyu Liu, Yuhang Mei, Jiaxuan Yang, Tian Wang, Mengqi Liu, Linxi Jiang
+10 more Russell Grant Snell, Blake Highet, Maurice A. Curtis, Liang Chen, Shi-Bin Li, Jinsong Wu, Menghan Zhang, Wensheng Li, Gong‐Hong Wei, Linya You
DOI: 10.1016/j.isci.2026.114692
Cited by: 1
References: 91

Abstract

OE) in the dorsal striatum selectively altered ultrasonic vocalizations (USVs), locomotor activity, and myelin basic protein expression. These results connect regulatory variation to lateralized gene control and circuit function relevant to vocal communication, and provide a multiregional resource to support mechanistic studies in human tissue and animal models.

Fields of Study & Subjects

Hemispheric Asymmetry in Neuroscience Stress Responses and Cortisol Transcranial Magnetic Stimulation Studies

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114692–114692
Publication date
14 January 2026
Language
EN