Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination

iScience 2026 Open access

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Authors: Weixing Yan, Dong Xiang, Li Du, Di Zhu, Qi Jia, Yuting Liu, Siyu Wang, Li Liu, Haihao Guan, Yelin Zhao, Guan Jiang, Sijia Gao
+1 more Hui Wang
DOI: 10.1016/j.isci.2026.114718
Cited by: 1
References: 59

Abstract

deletion inhibited microglial clearance of myelin debris, independent of reduced microglia numbers. This defect was associated with diminished autophagy. Together, these findings establish Aurkb as a key regulator of microglial development, homeostasis, and responses to remyelination.

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Neurogenesis and neuroplasticity mechanisms Nerve injury and regeneration

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114718–114718
Publication date
20 January 2026
Language
EN