Activation of SNr GABA neurons drives liver-brain-eye axis dysfunction in hepatic encephalopathy

iScience 2026 Open access

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Authors: Kenan Li, Zhenhua Wang, Shaoheng Li, Feifei Wu, Yunhu Bai, Shujiao Li, Changlei Zhu, Ziwei Ni, Shuai Zhang, Yousheng Wu, Fei Tian, Nannan Liu
+5 more Chen Tao, Cailian Ruan, ZuoMing Zhang, Yanling Yang, Yayun Wang
DOI: 10.1016/j.isci.2026.114720
Cited by: 0
References: 84

Abstract

) projections to the superior colliculus (SC) under AHE conditions. Chemogenetic inhibition of this pathway restored retinal function, normalized visual signal transmission, and reduced retinal γ-aminobutyric acid (GABA) release. These findings identify SNr-SC signaling as a key neural mechanism driving liver-brain-eye axis dysfunction in HE.

Fields of Study & Subjects

Neuroscience and Neuropharmacology Research Liver Disease and Transplantation Visual perception and processing mechanisms

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114720–114720
Publication date
16 January 2026
Language
EN