KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progression

iScience 2026 Open access

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Authors: Xianbin Huang, Yanqiu Meng, Jielong Song, Yizi Zhu, Li Jian Shao, Yan Xi, Xiaodong Peng, Yaoyi Xiong
DOI: 10.1016/j.isci.2026.114734
Cited by: 0
References: 37

Abstract

experiments. Collectively, we demonstrate that KNSTRN knockdown induces intracellular ROS accumulation and lysosomal dysfunction, thereby disrupting autophagic flux and inhibiting BLCA progression.

Fields of Study & Subjects

Autophagy in Disease and Therapy Calcium signaling and nucleotide metabolism Bladder and Urothelial Cancer Treatments

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114734–114734
Publication date
20 January 2026
Language
EN