Disruption of chrna5 blunts aversion and adaptive transcriptomic responses to nicotine and alcohol

iScience 2026 Open access

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Authors: Tanisha Goel, Joshua Raine, Caroline Kibat, Jeff Winxin Collado, Tirtha Das Banerjee, Ajay Sriram Mathuru
DOI: 10.1016/j.isci.2026.114735
Cited by: 1
References: 113

Abstract

mutants also exhibited drug-independent changes in appetite and circadian rhythms. We expect these results to give new insights into genetic predisposition that modulates vulnerability to nicotine and alcohol abuse.

Fields of Study & Subjects

Zebrafish Biomedical Research Applications Nicotinic Acetylcholine Receptors Study Neurotransmitter Receptor Influence on Behavior

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114735–114735
Publication date
20 January 2026
Language
EN