Butyrate ameliorates doxorubicin-induced heart failure by inhibiting cardiomyocyte ferroptosis through the gut-heart axis

iScience 2026 Open access

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Authors: Shibin Zeng, Qing Xie, Rong Zhang, Ting Yang, Dan Liu, Jiani Zhang, Shudong Ma, Xiaozhong Qiu
DOI: 10.1016/j.isci.2026.114754
Cited by: 3
References: 48

Abstract

levels, and inhibited cardiomyocyte ferroptosis. Further results confirmed that NaB mitigated DOX-induced ferroptosis via the GPX4/GSH pathway. Collectively, this study indicated that butyrate ameliorates DIHF by inhibiting cardiomyocyte ferroptosis through the gut-heart axis, providing translational potential for microbiota-targeted cardioprotective strategies in DIHF.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Inflammatory Biomarkers in Disease Prognosis Chemotherapy-induced cardiotoxicity and mitigation

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114754–114754
Publication date
21 January 2026
Language
EN