Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer

iScience 2026 Open access

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Authors: Aaron J. Bernstein, Renske Keeman, Amber N. Hurson, Fiona M. Blows, Manjeet K. Bolla, Jodi L. Miller, Roger L. Milne, Hugo Horlings, Alexandra J. van den Broek, Clara Bodelon, James M. Hodge, Alpa V. Patel
+53 more Lauren R. Teras, Federico Canzian, Rudolf Kaaks, Hermann Brenner, Ben Schöttker, Sabine Behrens, Jenny Chang-Claude, Tabea Maurer, Nadia Obi, Fergus J. Couch, H.Raza Ali, Carlos Caldas, Irene Andrulis, Gord Glendon, Anna Marie Mulligan, Wilma E. Mesker, Agnes Jager, Annette Heemskerk-Gerritsen, Peter Devilee, Scott M. Lawrence, Jolanta Lissowska, Karun Mutreja, Thomas Ahearn, Stephen Chanock, Máire A. Duggan, Diana Eccles, J. Louise Jones, Will Tapper, Antoinette Hollestelle, Maartje Hooning, John W.M. Martens, Carolien H. M. van Deurzen, Angela Cox, Simon S. Cross, Mikael Hartman, LI Jing-mei, Thomas Choudary Putti, Ute Hamann, Muhammad Rashid, Ania Jakubowska, Nicki J Camp, Melissa H. Cessna, Amy Berrington de González, Katarzyna Białkowska, J. Gronwald, Jan Lubiński, Siddhartha Yadav, Pietro Liò, Doug F. Easton, Mustapha Abubakar, Montse Garcia-Closas, Paul D.P. Pharoah, Marjanka K. Schmidt
DOI: 10.1016/j.isci.2026.114759
Cited by: 2
References: 25

Abstract

TIICs were associated with a poorer prognosis in ER-positive disease in multi-marker models. These results may have implications for breast cancer immunotherapy.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Immune cells in cancer Single-cell and spatial transcriptomics

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
2
Pages
114759–114759
Publication date
21 January 2026
Language
EN