Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling

iScience 2026 Open access

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Authors: Biting Zhou, Wangxiong Hu, Wei Dai, Kailun Xu, Lihong Liu, Shu Sen Zheng, Qichun Wei, Ting Chen
DOI: 10.1016/j.isci.2026.114783
Cited by: 0
References: 31

Abstract

mutational profiles. These findings implicate CASP in CRC progression and support its potential as a prognostic biomarker and therapeutic target by disrupting CASP-driven signaling.

Fields of Study & Subjects

Cancer-related Molecular Pathways Genetic factors in colorectal cancer Cancer Mechanisms and Therapy

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114783–114783
Publication date
30 January 2026
Language
EN