Biomimetic hydrogel for the construction of patient-derived bladder cancer organoids with aggressive growth

iScience 2026 Open access

Read full text
Authors: Jin Zhang, Jiaxin Wang, Xiaofeng Hu, Wei Jia, Ziyuan Zhou, Gaohaer Kadeerhan, Wenmin Guo, Jun Tian, Hong Guo, Ling Guo, Dongwen Wang
DOI: 10.1016/j.isci.2026.114786
Cited by: 0
References: 75

Abstract

mesoscale collagen's role, enhancing BCO viability, invasiveness, and migration, aligning with tumor growth patterns. These organoids preserved tumor architecture and mutations, showing drug sensitivities similar to those of parental tissue-derived cells and correlating with patient outcomes. This suggests that such organoids can serve as preclinical models to inform therapeutic strategies.

Fields of Study & Subjects

3D Printing in Biomedical Research Hydrogels: synthesis properties applications Tissue Engineering and Regenerative Medicine

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114786–114786
Publication date
27 January 2026
Language
EN