Advances in the study of nucleolar small RNAs in colorectal cancer

iScience 2026 Open access

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Authors: Ziwen Yuan, Yafang Chen, Sicong Liu, Jiyuan Yang, Can Tang, Xuan He, Shiyu Wang, Xudong Wang
DOI: 10.1016/j.isci.2026.114789
Cited by: 1
References: 132

Abstract

Colorectal cancer (CRC) is an important public health challenge worldwide, which has led to a continuous search for more precise diagnostic strategies. Recent studies have revealed that small nucleolar RNAs (snoRNAs) play an important role in CRC. In this article, we first summarize the molecular characteristics and physiological functions of snoRNAs, and then we discuss their mechanisms of action in colorectal carcinogenesis. A key focus is on the emerging potential of snoRNAs as liquid biopsy biomarkers and their prospects for clinical translation in cancer management.

Fields of Study & Subjects

RNA modifications and cancer Cancer-related molecular mechanisms research MicroRNA in disease regulation

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114789–114789
Publication date
24 January 2026
Language
EN