Submedius thalamic inputs shape the presynaptic architecture of layer 5 orbitofrontal cortex in mice

iScience 2026 Open access

Read full text
Authors: Gen‐ichi Tasaka, Mitsue Hagihara, Haruna Kobayashi, Miho Kihara, Takaya Abe, Kazunari Miyamichi
DOI: 10.1016/j.isci.2026.114828
Cited by: 0
References: 66

Abstract

imaging demonstrated pup retrieval-related activity in both SMT and MD, with SMT exhibiting learning-related plasticity. Projection-specific chemogenetic silencing demonstrated that SMT modulates OFC activity during pup retrieval, although its behavioral relevance appeared limited. Collectively, our study provides a presynaptic map of OFC layer 5 neurons and a proof of concept for selective manipulation of the SMT as a previously understudied thalamic input to the OFC.

Fields of Study & Subjects

Neuroscience and Neuropharmacology Research Memory and Neural Mechanisms Neurotransmitter Receptor Influence on Behavior

Publication details

Journal / source
iScience
Volume
29
Issue
2
Pages
114828–114828
Publication date
29 January 2026
Language
EN