Discovery of key regulators in classical monocyte phenotypes linked to COVID-19 severity using single-cell multi-omics sequencing
Abstract
perturbations, we revealed that ETS1 is a key driver of IL7R + monocytes with T cell-like signaling features and that JDP2 is a repressor that maintains the profibrotic, anti-inflammatory identity of CD163+ monocytes by suppressing AP-1 activity. These subtypes were enriched in the moderate-to-critical stages and exhibited signaling pathways associated with tissue remodeling and immune suppression. Our findings define monocyte heterogeneity as linked to COVID-19 severity and identify ETS1 and JDP2 as central regulators, offering insights into immune dysregulation, potential therapeutic targets for fibrosis, and long-term sequelae.
Fields of Study & Subjects
Immune responses and vaccinations
vaccines and immunoinformatics approaches
Single-cell and spatial transcriptomics
Publication details
- Journal / source
- iScience
- Publisher
- Elsevier BV
- Volume
- 29
- Issue
- 3
- Pages
- 114849–114849
- Publication date
- 30 January 2026
- Language
- EN