Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses

iScience 2026 Open access

Read full text
Authors: Victoria Simanihuruk, Yurie Kida, Kosuke Takada, Harumi Yamaguma, Natsumi Kameoka, Itsuki Anzai, Shintaro Shichinohe, Satoshi Obika, Yuuya Kasahara, Tokiko Watanabe
DOI: 10.1016/j.isci.2026.114851
Cited by: 1
References: 59

Abstract

) values and favorable selectivity indices. GBF1-targeting ASOs thus represent a promising host-directed antiviral approach for controlling respiratory RNA viruses.

Fields of Study & Subjects

SARS-CoV-2 and COVID-19 Research interferon and immune responses Pharmacological Receptor Mechanisms and Effects

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114851–114851
Publication date
30 January 2026
Language
EN