Progesterone-driven stabilization of hybrid E/M states in amniotic epithelial cells enhances regeneration and immune modulatory capacities

iScience 2026 Open access

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Authors: Angelo Canciello, Alberto Maria Crovace, Verdiana Di Giulio, Giuseppe Prencipe, Mohammad El Khatib, Valentina Russo, Marta Guadalupi, Annunziata Mauro, Antonio Crovace, Oriana Di Giacinto, Maura Turriani, Laura Pierdomenico
+2 more Marco Marchisio, Barbara Barboni
DOI: 10.1016/j.isci.2026.114867
Cited by: 0
References: 53

Abstract

tendon differentiation on PLGA-fleeces and in an ovine tendon injury model, where the transplantation of hybrid AECs accelerated early regeneration. This effect was associated with a timely transition from inflammation to proliferation, mediated by macrophage polarization and extracellular matrix remodeling. Our findings reveal that P4 maintains AECs in a functionally hybrid E/M state, conferring regenerative and immunomodulatory advantages. These results offer insights into the physiological regulation of EMP and support the therapeutic relevance of hybrid AECs as promising candidates for cell-based regenerative medicine therapy.

Fields of Study & Subjects

Mesenchymal stem cell research Tendon Structure and Treatment Pluripotent Stem Cells Research

Publication details

Journal / source
iScience
Volume
29
Issue
3
Pages
114867–114867
Publication date
31 January 2026
Language
EN