FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS-FTD-associated CHCHD10S59L in Drosophila and human cells

iScience 2026 Open access

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Authors: Swati Maitra, Do-Won Ham, Minwoo Baek, Yun-Jeong Choe, Nam Chul Kim
DOI: 10.1016/j.isci.2026.114879
Cited by: 1
References: 24

Abstract

-linked ALS-FTD, while emphasizing the need to carefully consider the effects of the PINK1/Parkin pathway, as it is generally recognized as a protective pathway.

Fields of Study & Subjects

Phosphodiesterase function and regulation Amyotrophic Lateral Sclerosis Research Protein Kinase Regulation and GTPase Signaling

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114879–114879
Publication date
3 February 2026
Language
EN