Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer

iScience 2026 Open access

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Authors: Huabo Wang, Jie Lu, Colin Henchy, Steven J. Mullett, Adam C. Richert, Eric S. Goetzman, Ahmet Toksoz, Leonardo Hale, Brandon B. Wang, Nelli Mnatsakanyan, Edward V. Prochownik
DOI: 10.1016/j.isci.2026.114889
Cited by: 2
References: 106

Abstract

functions in reverse as an ATPase to limit excess ATP accumulation. The uncoupling of TCA-cycle-derived anabolic substrate production from membrane hyperpolarization and ATP overproduction by a smaller population of highly efficient mitochondria allows TCA-cycle-generated anabolic precursors to match those generated via glycolysis.

Fields of Study & Subjects

Mitochondrial Function and Pathology ATP Synthase and ATPases Research Cancer Hypoxia and Metabolism

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114889–114889
Publication date
3 February 2026
Language
EN