USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD

iScience 2026 Open access

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Authors: Rui Chen, Xin-Hao Han, Zhen Zhang, Xiao-Jian Han, Junping Xie
DOI: 10.1016/j.isci.2026.114916
Cited by: 2
References: 53

Abstract

. These findings establish USP5-mediated stabilization of CD73 as a central mechanism underlying glycolytic metabolism and osimertinib resistance in LUAD, highlighting the USP5/CD73 pathway as a promising prognostic indicator and therapeutic target for LUAD treatment.

Fields of Study & Subjects

Adenosine and Purinergic Signaling Ubiquitin and proteasome pathways PI3K/AKT/mTOR signaling in cancer

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114916–114916
Publication date
6 February 2026
Language
EN