USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis

iScience 2026 Open access

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Authors: Zhong-e Chen, Cheng-qin Sun, Ye Wang, Xiao-juan Duan, Huaxing Ma, Xiaoqian Zhou, Shao-jie Chen, Pai-lan Peng
DOI: 10.1016/j.isci.2026.114927
Cited by: 1
References: 43

Abstract

experiments showed that MCM3 knockdown significantly suppressed xenograft tumor growth. In summary, MCM3 functions as a key oncoprotein. USP1-mediated deubiquitination of MCM3 influences the Keap1-Nrf2 axis, regulates mitophagy, and facilitates HCC progression. MCM3 may be a potential therapeutic target for liver cancer.

Fields of Study & Subjects

Genomics phytochemicals and oxidative stress Autophagy in Disease and Therapy Sirtuins and Resveratrol in Medicine

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114927–114927
Publication date
6 February 2026
Language
EN