Cyclin C promotes pancreatic developmentand suppresses cancer initiation by maintenance of the autophagy-lysosome pathway

iScience 2026 Open access

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Authors: Sara E. Hanley, Kathy Qi Cai, Stephen D. Willis, David C. Stieg, Andres J. Klein-Szanto, Kerry S. Campbell, Randy Strich
DOI: 10.1016/j.isci.2026.114949
Cited by: 1
References: 72

Abstract

pancreata did not undergo cell death, suggesting a role for the mitochondrial cyclin C function. Finally, loss of CCNC activity rendered cells hypersensitive to proteasome inhibitors. These findings identify multiple roles for cyclin C in promoting pancreatic health and suggest a new strategy to target pancreatic neoplasms by inhibiting proteasome function.

Fields of Study & Subjects

Autophagy in Disease and Therapy Cancer-related Molecular Pathways Hedgehog Signaling Pathway Studies

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114949–114949
Publication date
7 February 2026
Language
EN