Circ_0003323 binds METTL1 to mediate KLK6 m7G methylation modification and promote the progression of colorectal cancer

iScience 2026 Open access

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Authors: Mengyang Zhang, Wen Li, Jiachun Ma, Hongye Mu, Yubo Zhao, Ling Qi, Donglian Liu, Tieli Peng
DOI: 10.1016/j.isci.2026.114999
Cited by: 2
References: 25

Abstract

knockdown and METTL1 knockdown achieved better tumor inhibitory effect. Our findings provide insights into the mechanism of CRC progression and present potential therapeutic targets for the treatment of CRC.

Fields of Study & Subjects

Circular RNAs in diseases RNA modifications and cancer Kruppel-like factors research

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
114999–114999
Publication date
12 February 2026
Language
EN